Based on the acclaimed book by neurologist Oliver Sacks, director Penny Marshall's hit 1990 drama stars Robin Williams as Dr. Malcolm Sayer. Sayer is a neurologist who discovers that the drug L-Dopa can be used to "unlock" patients in a mental hospital from the mysterious sleeping sickness that has left them utterly immobilized. Leonard (Robert De Niro) is one such patient who awakens after being in a comatose state for 30 years, leaving Sayer to guide Leonard in adjusting to the world around him. Penelope Ann Miller costars as the daughter of another patient, with whom Leonard falls tenuously in love. Earning Oscar nominations for best picture, actor, and screenplay, this moving fact-based drama was a hit with critics and audiences alike. --Jeff Shannon