Two young girls, Mei and Satsuki, move into a new home that is close to the hospital that their mother is in. In their yard is an extremely large tree which is home to three Totoros, gods of the forest. Soon after, news from the hospital comes up that their mother can't come home as promised, so Mei (the younger daughter) runs away from home to visit her mom. Satsuki then needs to turn to Totoro for help in finding her sister.